• These results from the present study are summarized in Table

  2024-02-19

  

  These results from the present study are summarized in Table 1. Eight drugs (doxorubicin, epirubicin, daunorubicin, idarubicin, irinotecan, imatinib, sunitinib and gefitinib) inhibited 5-HT-induced 5-HT3A and 5-HT3AB currents; three (irinotecan, topotecan and mitoxantrone) showed different responses

• Control of retinal vascularization during development

  2024-02-19

  

  Control of retinal vascularization during development and OIR likely involves close interactions among endothelial cells, neurons and glial histone demethylase inhibitor (microglial and astrocytes) (see Fig. 2). In particular, the interaction between endothelial tip cells and astrocytes plays a cri

• br Conflict of interest statement br Benign prostatic hyperp

  2024-02-19

  

  Conflict of interest statement Benign prostatic hyperplasia (BPH) is a highly complex process characterized by an increased number of epithelial and stromal PKI-402 in the transition zone. , , Autopsy studies by McNeal detail the evolution of histological changes within these 2 cellular compa

• br Clinical realities br Commentary on uses

  2024-02-19

  

  Clinical realities Commentary on uses of selective 17,20 lyase inhibitors If continued monitoring of these same parameters along with tracking of circulating ACTH in human trials confirms these new drugs are the long sought after 17,20 lyase inhibitors, then we may for the first time be able t

• Taking together findings from our study and

  2024-02-19

  

  Taking together findings from our study and that from the literature, we propose a model (to be experimentally confirmed) of possible intracellular mechanism of NA-induced regulation of Na-K ATPase subunit expression (Fig. 8). NA acting on α1-AR modulates the α1- and α3-subunit expressions of Na-K A

• In many cells AR mediated activation of PLC has been

  2024-02-19

  

  In many A 804598 α1-AR mediated activation of PLC has been shown to be the downstream process for NA-induced signalling. The activated PLC initiates subsequent signalling by breakdown of PIP2 to IP3 and DAG (Fisher and Agranoff, 1987) and the process continues. To confirm if such mechanism exists i

• Hypoxia induced replication arrest has

  2024-02-19

  

  Hypoxia-induced replication arrest has been demonstrated in a variety of organisms in addition to mammals; including Zebrafish , , and (brine shrimp) which have been shown to survive for 4 years and longer in anoxic conditions . Despite this breadth of study, little is known about the mechanism of

• ATM is generally regarded to be the principal mediator

  2024-02-19

  

  ATM is generally regarded to be the principal mediator of the G1 DNQX disodium salt checkpoint, whereas the induction of the intra-S-phase and G2/M checkpoints are usually primarily related to ATR function. However, several studies have demonstrated that, depending on the cellular context and type

• Over expression of the inflammatory cytokines

  2024-02-19

  

  Over expression of the inflammatory cytokines, MMPs and COX-2 act as an important inducer of chronic inflammation. COX-2 catalyzes the biosynthesis of prostaglandins (PGs), and induced expression was observed in 839 stimulated with pro-inflammatory cytokines or bacterial lipopolysaccharide (Khanapu

• The protein kinase CK mediated phosphorylation of

  2024-02-19

  

  The protein kinase CK2-mediated phosphorylation of HMGN1 was implicated to be involved in age-associated amnesia in rats [31]. It was shown that the decreased level of HMGN1 phosphorylation due to the down-regulation of CK2 activity could cause amnesia in aged rats, whereas the treatment with protei

• Lorlatinib is an orally active brain penetrant

  2024-02-18

  

  Lorlatinib is an orally active brain penetrant cyclic 2-aminopyridine derivative that is a type I½ B ALK inhibitor (Fig. 5F) [61]. This medicinal is an effective antagonist against the more common L1196M and G1269A crizotinib-resistant mutations as well as the less common T1151Ins, L1152R, C1156Y, F

• br Autophagy and cell death pathways

  2024-02-10

  

  Autophagy and cell death pathways in ischemic stroke Although very important for the effects on post-ischemic AGK 2 injury, autophagy is not the only mechanism of action involved in cell death. Necrosis and apoptosis are two other distinct forms of cell death with great difference in morphology

• Previous studies have thus demonstrated that AR

  2024-02-09

  

  Previous studies have thus demonstrated that AR activation generally correlates with the promotion of urothelial carcinogenesis and cancer growth. In this article, we review available data suggesting their modulation through the AR pathway as well as correlations of AR signals with sensitivity to co

• Proteinase K The current guidelines are designed to optimize

  2024-02-09

  

  The current guidelines are designed to optimize the detection of IHC+FISH+ cases, most of which (but not all encountered in our study) being classically good responders to crizotinib therapy (resistance mechanisms to crizotinib therapy were not investigated in our study). In addition to the current

• In large biopsies series from ALK NSCLC treated

  2024-02-09

  

  In large biopsies series from ALK+ NSCLC treated patients, the number of detected mutations increased after second generation ALKi (Gainor et al., 2016) and in one study were present in 56% of the entire cohort (Shaw et al., 2013b). For example, the rate of G1202R mutations increases from 2% in pos

14365 records 130/958 page Previous Next First page 上5页 126127128129130 下5页 Last page