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To date over mutations in KCNQ have been
2019-05-21
To date, over 250 mutations in KCNQ1 have been found to be linked to LQT1 [34] and new LQT1 causing mutations continue to be identified. The vast majority of KCNQ1 mutations are single nucleotide substitutions (missense) or small insertion/deletions that localize to the S1-S6 transmembrane domains [
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Hay que remontar a la
2019-05-21
Hay que remontar abscisic acid la Guerra Civil española que movilizó a los poetas hispanoamericanos de una manera mucho más urgente que la Segunda Guerra Mundial, para hallar el origen de los lazos de Octavio Paz con Chile. En 1937 Octavio Paz recibió una invitación para participar en el Congreso In
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Ciertamente Espa a era poco y mal conocida Y ello
2019-05-21
Ciertamente, España era poco y mal conocida. Y ello no sólo ocurría con los radicales europeos, sino también con los latinoamericanos. Creo que la actividad intelectual de La Sagra puede ayudar LJI308 comprender por qué el joven Bilbao que regresa en 1850 del exilio francés ya no es el liberal ultra
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order StemRegenin 1 Findings Final data analysis included
2019-05-21
Findings Final data analysis included 28 households: nine from the Tulip filter group, 10 from Waterguard chlorination, and nine from the group who boiled water. Two households had incomplete data and were excluded from analysis. Before the intervention, 29 of 30 households were not treating their w
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There was a modest excess risk of mortality
2019-05-21
There was a modest excess risk of mortality associated with multidrug-resistant organisms, which was lower than that previously recorded in south Asia. There are methodological challenges in the attribution of excess neonatal mortality with antimicrobial resistance because of known confounding with
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A Cochrane review retained the three
2019-05-20
A 2015 Cochrane review retained the three community-based studies mentioned above and concluded that there was high-quality evidence of reduced risk of infection or omphalitis and death. The review also included two studies in which chlorhexidine was applied in a hospital setting: the above-describe
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Therefore if appropriate vitamin supplement times wk
2019-05-20
Therefore, if appropriate vitamin supplement (>3 times/wk) for pregnant women would reduce the serum levels of copper, which has been demonstrated in the current issue of the , is it possible that the fetus might escape a potentially toxic bioaccumulation of mercury and copper? Of course, the fetus
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PPCL were associated with a very poor prognosis The median
2019-05-20
PPCL were associated with a very poor prognosis. The median survival duration according to published small trials was short, ranging from 7 to 13 months, with less than 10% of patients having a median survival of more than 5 years. In the largest recently published epidemiological study, the median
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br Los dos libros que
2019-05-20
Los dos libros que I-BET-762 continuación se reseñan solo en parte coinciden en su objeto de estudio y el método de tratarlo. El libro de Hugo J. Verani ofrece una minuciosa interpretación de la poética de Octavio Paz, especialmente de la que domina en sus poemas extensos. También Evodio Escalante
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br Tuberculosis remains a global emergency and
2019-05-20
Tuberculosis remains a global emergency and continues to present major public health challenges worldwide. The actual global burden of tuberculosis can only be estimated because no accurate data are available from national country programmes from of high tuberculosis endemic countries. The WHO 201
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br Authorship br Conflict of interest
2019-05-20
Authorship Conflict of interest disclosure Introduction The Aurora kinases are serine/threonine protein kinases essential for regulation of normal EPZ015666 mitosis. Aurora kinases A (AAK) and B are overexpressed in hematologic malignancies, including acute myeloid leukemia (AML) and myelo
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br Discussion Our case demonstrates feasibility
2019-05-20
Discussion Our case demonstrates feasibility for improvement in erythropoiesis in a patient with poor predictor of ESA/G-CSF response/growth factor refractory, low-risk MDS who was treated with sertraline for co-morbid depression. Within 100 days concurrent administration of sertraline, ESA and G
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To overcome these resistance mechanisms in APL
2019-05-20
To overcome these resistance mechanisms in APL cells, a number of drugs have been tested. Tamibarotene is approximately 10 times more potent than ATRA as an in vitro inducer of differentiation, and is chemically more stable than ATRA [5]. Although the precise mechanism of the combination of tamibaro
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Two other groups subsequently published further data on iPSC
2019-05-20
Two other groups subsequently published further data on iPSCs models of ARVC that have improved our understanding of this disease. Kim et al. developed iPSC models using episomal methods from 2 ARVC patients, as well as with PKP2 mutations . Detailed electrophysiological characterization of mutant a
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Initial radiographs demonstrated an aggressive
2019-05-18
Initial radiographs demonstrated an aggressive lesion in the medial condyle of the distal right femur (Figs. 1A and B). CT obtained to characterize matrix showed an aggressive lesion with a focus of dense linear matrix (Fig. 2) with intervening lucent areas. The lesion was felt to be indeterminate a
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